Leonardo S. Barbosa, PhD

Physicist | Neuroscientist | Machine Learning Researcher

I bridge the gap between theoretical consciousness research and clinical application.

Currently, I am a Research Assistant Professor at the Fralin Biomedical Research Institute (Virginia Tech) and Co-Founder of Nebula Neuro. My work combines computational modeling (Deep Learning, Information Theory, Advanced Signal Processing) with novel biological measurements to understand mental health disorders.

Core Focus: Computational Psychiatry • Human Monoamine Measurement • Integrated Information Theory (IIT).


ACADEMIC Research & Phenomenology

My lab uses sub-second neurochemistry measurements in humans to determine how monoamines influence subjective experience and decision-making.

  • 1,200+ Citations (h-index 14)
  • → Developer of 1st-in-human monoamine sensing protocols
  • Google Scholar Profile

INDUSTRY Technological Impact

My research has led to the development of novel frameworks for AI-driven biomarker validation and FDA-compliant Real-World Evidence (RWE) generation.

  • Nebula Neuro: Co-Founder & Equity Holder. (Commercializing patent-pending biomarkers for mental health).
  • Key Competencies: Clinical Data Strategy, AI Auditing, & SaMD Validation.

Selected Works

A human amygdala dopamine, serotonin and norepinephrine measurement.

Bang*, Luo*, Barbosa*, et al. (2023) • Current Biology

Co-First Author. Achieved the first sub-second measurements of neuromodulators using standard clinical sEEG electrodes. Revealed that norepinephrine estimates correlate positively with stimuli during high-arousal states, unlocking new avenues for monitoring human affect.

Integrated Information Theory (IIT) 4.0

Albantakis*, Barbosa*, et al. (2023) • PLOS Computational Biology

Foundational work defining the physical postulates of consciousness. Developed the mathematical implementation for quantifying cause-effect power in conscious physical systems.